Analysis of the In-Host Dynamics of Tuberculosis and SARS-CoV-2 Coinfection

The coronavirus disease 2019 (COVID-19) is a respiratory that appeared in caused by virus called severe acute syndrome 2 (SARS-CoV-2). COVID-19 still spreading and causing deaths around the world. There real concern of SARS-CoV-2 coinfection with other infectious diseases. Tuberculosis (TB) bacterial Mycobacterium tuberculosis (Mtb). TB has been recorded many countries. It suggested associated death. Mathematical modeling an effective tool can help understand dynamics between new diseases well-known In this paper, we develop in-host model cytotoxic T lymphocytes (CTLs). investigates interactions healthy epithelial cells (ECs), latent Mtb-infected ECs, active SARS-CoV-2-infected free Mtb, SARS-CoV-2, CTLs. model’s solutions are proved to be nonnegative bounded. All equilibria their existence conditions calculated. Proper Lyapunov functions selected examine global stability equilibria. Numerical simulations implemented verify theoretical results. found six equilibrium points. These points reflect two states: mono-infection state where or occurs as single infection, infections occur simultaneously. parameters control movement these states should tested order better treatments for coinfected patients. Lymphopenia increases concentration particles thus worsen health status patient.